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NFL Week 6 kicks off Thursday night, as the Giants host the Eagles.
Here are the lines for every Week 6 matchup at DraftKings Sportsbook as of Oct. 12.
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(All times ET)
2025 NFL Week 6 Odds
THURSDAY, OCT. 9
Spread: Eagles -7 (Giants cover)
Over/Under: 40.5 (Over hits)
SUNDAY, OCT. 12
Spread: Broncos -7.5
Moneyline: Broncos -410, Jets +320
Over/Under: 43.5
Spread: Colts -8.5
Moneyline: Colts -470, Cardinals +360
Over/Under: 46.5
Spread: Cowboys -3
Moneyline: Cowboys -175, Panthers +145
Over/Under: 47.5
Spread: Rams -7
Moneyline: Rams -355, Ravens +280
Over/Under: 43.5
Spread: Chargers -3.5
Moneyline: Chargers -205, Dolphins +170
Over/Under: 45.5
Spread: Patriots -3.5
Moneyline: Patriots -192, Saints +160
Over/Under: 46.5
Spread: Steelers -6
Moneyline: Steelers -290, Browns +235
Over/Under: 37.5
Spread: Seahawks -1.5
Moneyline: Jaguars -105, Seahawks -115
Over/Under: 47.5
Spread: Raiders -3.5
Moneyline: Raiders -185, Titans +154
Over/Under: 41.5
Spread: Packers -14.5
Moneyline: Packers -1100, Bengals +700
Over/Under: 44.5
Spread: Buccaneers -3.5
Moneyline: Buccaneers -192, 49ers +160
Over/Under: 46.5
Spread: Chiefs -2.5
Moneyline: Chiefs -135, Lions +114
Over/Under: 52.5
MONDAY, OCT. 13
Spread: Bills -4.5
Moneyline: Bills -205, Falcons +170
Over/Under: 49.5
Spread: Commanders -4.5
Moneyline: Commanders -225, Bears +185
Over/Under: 49.5
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